visual studio - Why the debugger doesn't work

Question

My debugger is not working,
I'm putting a breakpoint, but in run, time visual studio doesn't stop on the breakPoint.
How to fix it?
There is nothing special in my application, it is a simple web application. I am using visual studio 2005.

I've created a new web application project, and on the default.aspx page there is a obout grid control, on the default.cs i am filling a datatable and putting it as datatasource for the grid.
I was able to debug it, suddenly the debugger is never hit.
note that the debugger is on the load event.

Answer 1

Find below the steps that solved my problem:

1. Delete ASP.NET temporary files from C:WindowsMicrosoft.NETFrameworkv2.0.50727Temporary ASP.NET Files
2. Change build configuration to debug from project properties.
3. Delete bin folder from your project.
4. Check if compilation debug is set to true in the web.config
5. iisreset
6. Rebuild the project.