coding style - Python `if x is not None` or `if not x is None`?

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Answer 1

There's no performance difference, as they compile to the same bytecode:

>>> import dis
>>> dis.dis("not x is None")
  1           0 LOAD_NAME                0 (x)
              2 LOAD_CONST               0 (None)
              4 COMPARE_OP               9 (is not)
              6 RETURN_VALUE
>>> dis.dis("x is not None")
  1           0 LOAD_NAME                0 (x)
              2 LOAD_CONST               0 (None)
              4 COMPARE_OP               9 (is not)
              6 RETURN_VALUE

Stylistically, I try to avoid not x is y, a human reader might misunderstand it as (not x) is y. If I write x is not y then there is no ambiguity.